Phenotypes Associated with This Genotype

Genotype
MGI:6267419

• Allelic Composition: Mlf1^tm1Swm/Mlf1^tm1Swm
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased splenocyte apoptosis ( J:266833 )

• of splenic B and T cells ex vivo upon cytokine depletion

• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation

• however, response to gamma-irradiation is normal

increased B cell number ( J:266833 )

• slight in the spleen

• however, splenic T cell and thymocyte numbers are normal

cellular

decreased splenocyte apoptosis ( J:266833 )

• of splenic B and T cells ex vivo upon cytokine depletion

• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation

• however, response to gamma-irradiation is normal

hematopoietic system

decreased splenocyte apoptosis ( J:266833 )

• of splenic B and T cells ex vivo upon cytokine depletion

• in response to cis-diammine-dichloroplatinum II (cisplatin), phorbol 12- myristate 13-acetate (PMA), dexamethasone (Dex), anti-Fas, and UV irradiation

• however, response to gamma-irradiation is normal

increased B cell number ( J:266833 )

• slight in the spleen

• however, splenic T cell and thymocyte numbers are normal