Analysis Tools
behavior/neurological
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• during the hidden platform trials of the Morris water maze, mice show deficiency in memorizing the platform location
• mice treated with ML246 for 5 weeks show improved performance in the Morris water maze during the hidden platform trials
• mice subjected to 16 weeks of voluntary running exercise show improved performance in the Morris water maze during the hidden platform trials
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homeostasis/metabolism
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• mice exhibit increased levels of both soluble and insoluble amyloid beta 42 in the brain
• 6 month old mice treated with ML246, a brain-penetrable autophagy-inducing small molecule, for 5 weeks show decreased levels of both soluble and insoluble amyloid beta 42 in the brain and a trend in plaque reduction, especially in the cerebral cortex
• however, expression of the precursor APP is unaffected in ML246 treated mice
• mice subjected to 16 weeks of voluntary running have lower levels of both soluble and insoluble amyloid beta 42 in brain and show a reduction of amyloid plaques than mice housed without running wheels, indicating that physical activity decreases amyloid burden
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nervous system
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• mice exhibit increased levels of both soluble and insoluble amyloid beta 42 in the brain
• 6 month old mice treated with ML246, a brain-penetrable autophagy-inducing small molecule, for 5 weeks show decreased levels of both soluble and insoluble amyloid beta 42 in the brain and a trend in plaque reduction, especially in the cerebral cortex
• however, expression of the precursor APP is unaffected in ML246 treated mice
• mice subjected to 16 weeks of voluntary running have lower levels of both soluble and insoluble amyloid beta 42 in brain and show a reduction of amyloid plaques than mice housed without running wheels, indicating that physical activity decreases amyloid burden
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Alzheimer's disease | DOID:10652 | J:244104 | ||
