Phenotypes Associated with This Genotype

Genotype
MGI:6198763

• Allelic Composition: Ppip5k2^{tm1a(EUCOMM)Wtsi}/Ppip5k2^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

abnormal auditory brainstem response waveform shape ( J:260825 )

• significant reduction in ABR wave I amplitudes at 24 kHz in older homozygous mice

increased or absent threshold for auditory brainstem response ( J:260825 )

• at P90 the threshold at 32 kHz is significantly increased

• at P120 and P150 the threshold at 24 kHz is significantly increased

impaired hearing ( J:260825 )

• late onset high-frequency progressive hearing loss

nervous system

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nonsyndromic deafness		DOID:0050563		J:260825