Phenotypes Associated with This Genotype

Genotype
MGI:6194625

• Allelic Composition: Tg(GFAP-ATXN7*92Q)2542Als/0
• Genetic Background: involves: C3H/HeJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

limb grasping ( J:113150 )

• mice exhibit clasping upon tail suspension beginning at 8-12 months of age

impaired coordination ( J:113150 )

• progressive incoordination

abnormal gait ( J:113150 )

• progressive incoordination and ultimately an abnormal gait at 16-20 months of age

• however, mice do not develop tremors, seizures, rigidity, or kyphosis

nervous system

abnormal Bergmann glial cell morphology ( J:113150 )

• degeneration of Bergmann glia radial fibers with disease progression

Purkinje cell degeneration ( J:113150 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
spinocerebellar ataxia type 7		DOID:0050958	OMIM:164500	J:113150