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Phenotypes Associated with This Genotype
Genotype
MGI:6193619
Allelic
Composition
Gt(ROSA)26Sortm1(CAG-AR)Zsu/Gt(ROSA)26Sor+
Tg(Osr1-cre)4Mrt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(CAG-AR)Zsu mutation (1 available); any Gt(ROSA)26Sor mutation (967 available)
Tg(Osr1-cre)4Mrt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

neoplasm
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions
• malignancy, with vascular invasion by neoplastic cells or local invasion of the tumor beyond the basement membrane into surrounding stromal tissues is seen in some mice
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells

reproductive system
• 13.6% of mice develop prostatic adenocarcinoma from 8-21 months of age
• tumors are poorly circumscribed and unencapsulated, comprised of haphazard acini and lobules of pleomorphic cells
• mice develop atypical proliferative lesions indicating prostatic intraepithelial neoplasia (mPIN) as early as 8 weeks of age
• 40.9% of mice exhibit mPIN lesions
• mPIN lesions are mainly cribriform structures with occasional stratification of cells, papilliferous structures and tufts of cells
• atypical epithelial cells that are irregular, larger than adjacent normal cells, and lacking normal polarity are seen in all prostatic lobes, including anterior, dorsal and ventral prostate
• foci of atypical cells partially fill the lumen of the ducts
• mice exhibit intraluminal glands forming within the original glands in the dysplastic lesions

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
prostate adenocarcinoma DOID:2526 J:234601


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
07/02/2024
MGI 6.13
The Jackson Laboratory