Phenotypes Associated with This Genotype

Genotype
MGI:6192631

• Allelic Composition: Tg(Erbb2*)#Maed/0; Tg(Foxa3-cre)1Khk/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:262746 )

• most mice die within 10 weeks after birth

neoplasm

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

digestive/alimentary system

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

endocrine/exocrine glands

abnormal pancreas morphology ( J:262746 )

• mice develop cystic lesions exhibiting papillary proliferation in almost all pancreatic tissue at 8 weeks of age

abnormal pancreatic acinar cell morphology ( J:262746 )

• loss of acinar cells in the pancreatic parenchyma, broad cystic changes, and elevated papillary lesions

increased pancreas tumor incidence ( J:262746 )

• papillary epithelial cells show dysplasia of low- to high-grades, resembling human intraductal papillary mucinous neoplasm with focal high-grade dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
benign neoplasm		DOID:0060072		J:262746