Phenotypes Associated with This Genotype

Genotype
MGI:6163637

• Allelic Composition: Dmd^em1Eno/Y
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased grip strength ( J:253191 )

♂ • grip strength analysis indicates a decrease in muscle strength by 5 months of age

homeostasis/metabolism

increased creatine kinase level ( J:253191 )

♂ • serum creatine kinase levels are elevated by 2 months of age

immune system

myositis ( J:253191 )

♂ • mice exhibit inflammatory infiltration in muscles by 2 months of age

muscle

skeletal muscle necrosis ( J:253191 )

♂ • muscles exhibit necrosis by 3 weeks of age

myositis ( J:253191 )

♂ • mice exhibit inflammatory infiltration in muscles by 2 months of age

increased variability of skeletal muscle fiber size ( J:253191 )

♂ • muscles show variability in fiber size with aggregated necrotic, regenerative fibers with centralized nuclei, and the presence of few revertant fibers

centrally nucleated skeletal muscle fibers ( J:253191 )

♂ • muscles show regenerative fibers with centralized nuclei

dystrophic muscle ( J:253191 )

♂ • mice exhibit severely dystrophic muscle with necrotic fibers and inflammatory infiltration by 2 months of age

cellular

skeletal muscle necrosis ( J:253191 )

♂ • muscles exhibit necrosis by 3 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:253191