Analysis Tools
behavior/neurological
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• locomotor activity is only 60% of littermate controls by 21-23 months of age
• treatment with a high dose of apomorphine increases locomotor activity to 171% of their habituation control levels
• mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity
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homeostasis/metabolism
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• mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites
• dopamine turnover is elevated by 50% in mice exposed to combined pesticides
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• mice exposed to progressive treatments of combined pesticides show a persistent reduction of about 70% in locomotor activity
• mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates
• mice exposed to combined pesticides exhibit a 56% decrease in the level of dopamine and decreased trends for its metabolites, a 40% reduction in dihydroxyphenylacetic acid (DOPAC) levels, a 20% non-statistically significant decrease in homovanillic acid, and a 50% elevation in dopamine turnover
• however, no changes in 5HT levels in the striatum are seen in mice exposed to combined pesticides
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nervous system
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• mice show a significant loss of TH+ neurons across time in the substantia nigra pars compacta, with an approximate 19% loss at 8.5 months and approximate 55% loss at 19 months of age
• however, inclusions are not seen in the substantia nigra pars compacta
• mice treated with combined pesticides show a greater loss of dopaminergic (TH+) neurons than control littermates
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:96494 | |
