Phenotypes Associated with This Genotype

Genotype
MGI:5907353

cx3

• Allelic Composition: Lmna^tm1Stw/Lmna^tm1Stw; Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:227485 )

• die earlier than mice homozygous for the Lmna mutation alone

cardiovascular system

dilated heart left ventricle ( J:227485 )

• dilation is more severe than in mice homozygous for the Lmna mutation alone

decreased cardiac muscle contractility ( J:227485 )

• cardiac dysfunction is more severe than in mice homozygous for the Lmna mutation alone

muscle

decreased cardiac muscle contractility ( J:227485 )

• cardiac dysfunction is more severe than in mice homozygous for the Lmna mutation alone