Phenotypes Associated with This Genotype

Genotype
MGI:5907350

hm1

• Allelic Composition: Mlip^{tm1.1(cre)Dzw}/Mlip^{tm1.1(cre)Dzw}
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased myocardial fiber size ( J:227485 )

• greater increase in cross-sectional area following transverse aortic constriction compared to controls

increased heart left ventricle weight ( J:227485 )

• increase in absolute and relative left ventricular mass at 11 months of age but not in mice at 3 or 6 months of age

dilated heart left ventricle ( J:227485 )

• increase in left ventricular dimension in aged mice

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

cardiac fibrosis ( J:227485 )

• extensive fibrosis following transverse aortic constriction

abnormal cardiovascular system physiology ( J:227485 )

• depressed cardiac function in older mice

• however, no detectable cardiac defects in young mice

decreased cardiac muscle contractility ( J:227485 )

• decrease in ejection fraction and fractional shortening at 11 and 18 months of age but not at 3 or 6 months of age

• dramatic decrease following transverse aortic constriction

abnormal response of heart to induced stress ( J:227485 )

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

increased response of heart to induced stress ( J:227485 )

• dramatic decrease in cardiac contraction and increase in fibrosis and cardiomyocyte size following transverse aortic constriction

homeostasis/metabolism

abnormal response of heart to induced stress ( J:227485 )

• transverse aortic constriction induced dramatic left ventricular dilation unlike in wild-type controls where this treatment induces left ventricular hypertrophy

increased response of heart to induced stress ( J:227485 )

• dramatic decrease in cardiac contraction and increase in fibrosis and cardiomyocyte size following transverse aortic constriction

muscle

increased myocardial fiber size ( J:227485 )

• greater increase in cross-sectional area following transverse aortic constriction compared to controls

decreased cardiac muscle contractility ( J:227485 )

• decrease in ejection fraction and fractional shortening at 11 and 18 months of age but not at 3 or 6 months of age

• dramatic decrease following transverse aortic constriction