Phenotypes Associated with This Genotype

Genotype
MGI:5904949

• Allelic Composition: Tg(Myh6-Rab1a)highGwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:134581 )

• mice die at around 43 days of age and none are viable past 47 days of age

cardiovascular system

enlarged heart ( J:134581 )

• hearts are enlarged with dilated cardiac chambers and atria containing laminar thrombus

increased heart weight ( J:134581 )

• heart weight to body weight ratio is increased in 6 week old mice

cardiac hypertrophy ( J:134581 )

dilated cardiomyopathy ( J:134581 )

• dilation of cardiac chambers and an increase in ventricular dimension indicates dilated cardiomyopathy

• however, no cardiomyocyte dropout or myocardial fibrosis is seen and no apoptosis in ventricular cardiomyocytes

decreased ventricle muscle contractility ( J:134581 )

• left ventricular fractional shortening is reduced in 6 week old mice

• however, left ventricular thickness is similar to controls

abnormal heart echocardiography feature ( J:134581 )

• end-systolic dimension and end-diastolic dimension, measured by echocardiography, are increased in 6 week old mice

congestive heart failure ( J:134581 )

muscle

dilated cardiomyopathy ( J:134581 )

• dilation of cardiac chambers and an increase in ventricular dimension indicates dilated cardiomyopathy

• however, no cardiomyocyte dropout or myocardial fibrosis is seen and no apoptosis in ventricular cardiomyocytes

decreased ventricle muscle contractility ( J:134581 )

• left ventricular fractional shortening is reduced in 6 week old mice

• however, left ventricular thickness is similar to controls

growth/size/body

enlarged heart ( J:134581 )

• hearts are enlarged with dilated cardiac chambers and atria containing laminar thrombus

increased heart weight ( J:134581 )

• heart weight to body weight ratio is increased in 6 week old mice

cardiac hypertrophy ( J:134581 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:134581