Phenotypes Associated with This Genotype

Genotype
MGI:5897625

• Allelic Composition: Tg(TG-RET/NCOA4)3209Rstn/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal thyroid gland morphology ( J:51366 )

• architecture of thyroids is severely altered and thyroglobulin production is active

abnormal thyroid follicular cell morphology ( J:51366 )

• glandular hypertrophy is due to follicular cell hyperplasia

enlarged thyroid gland ( J:51366 )

• hypertrophy of the thyroid gland is seen starting at 2 months of age, with each lobe on average 3-4 times normal size

increased thyroid carcinoma incidence ( J:51366 )

• thyroids from mice younger than 3 months of age show signs of cellular transformation characterized as follicular cell hyperplasia and dysplastic follicles

• mice 3 months of age or older develop solid subtype of papillary thyroid carcinoma

• thyroid carcinomas present as large regions of tissue devoid of follicles or papillae

neoplasm

increased thyroid carcinoma incidence ( J:51366 )

• thyroids from mice younger than 3 months of age show signs of cellular transformation characterized as follicular cell hyperplasia and dysplastic follicles

• mice 3 months of age or older develop solid subtype of papillary thyroid carcinoma

• thyroid carcinomas present as large regions of tissue devoid of follicles or papillae

increased metastatic potential ( J:51366 )

• 33% of mice show metastasis in lymph nodes, with the metastatic tumor showing papillary features of thyroid carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid gland papillary carcinoma		DOID:3969	OMIM:188550	J:51366