Phenotypes Associated with This Genotype

Genotype
MGI:5897605

• Allelic Composition: Ddah1^tm1.1Geno/Ddah1^tm1.1Geno
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal amino acid level ( J:234529 )

♂ • following overnight culture in Krebs buffer, mutant aortas show a 50% increase in asymmetrical dimethylarginine (ADMA) release

♂ • however, symmetrical dimethylarginine release is unaffected

abnormal circulating amino acid level ( J:234529 )

♂ • at 10-12 weeks of age, male mice show a significant increase in plasma asymmetrical dimethylarginine (ADMA) levels