Phenotypes Associated with This Genotype

Genotype
MGI:5896572

cx2

• Allelic Composition: Esyt2^{Gt(AN0678)Wtsi}/Esyt2^{Gt(AN0678)Wtsi}; Esyt3^{tm1d(EUCOMM)Wtsi}/Esyt3^{tm1d(EUCOMM)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6N
• Cell Lines: EPD0458_5_A10

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:232605 )

• fewer than expected mice are born

• however, surviving mice exhibit normal development, viability, survival, reproduction and organ development (lung, testis and spleen)

cellular

increased sensitivity to induced cell death ( J:232605 )

• mouse embryonic fibroblasts are less resistance to FGF serum withdrawal compared with control cells

decreased cell migration ( J:232605 )

• of FGF-stimulated mouse embryonic fibroblasts

increased cellular sensitivity to oxidative stress ( J:232605 )

• in mouse embryonic fibroblasts

homeostasis/metabolism

increased cellular sensitivity to oxidative stress ( J:232605 )

• in mouse embryonic fibroblasts