Phenotypes Associated with This Genotype

Genotype
MGI:5806468

• Allelic Composition: Tg(Ela-KRAS*G12D)9Eps/0; Tg(Mt1-TGFBR2*)AM3Epb/0
• Genetic Background: involves: C57BL/6 * FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreas morphology ( J:231759 )

♂ • expansion of the pancreatic stroma

pancreas fibrosis ( J:231759 )

♂ • pancreatic lesions are accompanied with more severe fibrosis and heavy matrix deposition

pancreatic acinar-to-ductal metaplasia ( J:231759 )

♂ • mice develop pancreatic acinar-to-ductal metaplasia

increased pancreas tumor incidence ( J:231759 )

♂ • mice show extensive intraductal papillary neoplasm development and associated parenchymal loss

abnormal pancreas physiology ( J:231759 )

♂ • increase in proliferating cell nuclear antigen (PCNA) staining throughout the entire pancreas

pancreas inflammation ( J:231759 )

♂ • mice display marked pancreatic inflammation

hematopoietic system

increased regulatory T cell number ( J:231759 )

♂ • total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

immune system

pancreas inflammation ( J:231759 )

♂ • mice display marked pancreatic inflammation

increased regulatory T cell number ( J:231759 )

♂ • total T-cell infiltration near pancreatic lesions is increased, with increased CD3/pSMAD2+ and CD3/FOXP3+ cell (suppressive/anergic regulatory T lymphocytes) infiltration but very little CD8+ infiltration

neoplasm

increased pancreas tumor incidence ( J:231759 )

♂ • mice show extensive intraductal papillary neoplasm development and associated parenchymal loss

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:231759