Phenotypes Associated with This Genotype

Genotype
MGI:5804696

• Allelic Composition: Cox6a1^{tm1(KOMP)Wtsi}/Cox6a1^{tm1(KOMP)Wtsi}
• Genetic Background: involves: C57BL/6JJcl * C57BL/6N
• Cell Lines: EPD0412_2_C09

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal motor coordination/balance ( J:230212 )

• mice have difficulty walking

impaired coordination ( J:230212 )

• 7-8 week old mice show a decreased latency to fall on the rotarod

liver/biliary system

abnormal liver physiology ( J:230212 )

• Cox activity and ATP contents in liver cells are decreased

muscle

abnormal muscle morphology ( J:230212 )

• neurogenic muscular changes including small angular fiber and small group atrophy

muscular atrophy ( J:230212 )

• small group atrophy

nervous system

abnormal sciatic nerve morphology ( J:230212 )

• thinned sciatic nerves

abnormal nerve conduction ( J:230212 )

• mice show delayed motor nerve conduction velocity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Charcot-Marie-Tooth disease recessive intermediate D		DOID:0110203	OMIM:616039	J:230212