Phenotypes for Dmd Utrn MGI:5795669 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Dmd^mdx/Y Utrn^tm1Jrs/Utrn⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/10ScSn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmd^mdx mutation (33 available); any Dmd mutation (167 available)
Utrn^tm1Jrs mutation (2 available); any Utrn mutation (306 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

diaphragmitis ( J:140282 )

• endomysial inflammation in the diaphragm is more severe at 3 months of age than in single Dmd^mdx hemizygous males

myositis ( J:140282 )

• endomysial inflammation in quadriceps is more severe at 3 months of age than in single Dmd^mdx hemizygous males

muscle

diaphragmitis ( J:140282 )

• endomysial inflammation in the diaphragm is more severe at 3 months of age than in single Dmd^mdx hemizygous males

myositis ( J:140282 )

• endomysial inflammation in quadriceps is more severe at 3 months of age than in single Dmd^mdx hemizygous males

skeletal muscle endomysial fibrosis ( J:140282 )

• mice develop mild endomysial fibrosis in quadriceps at 6 months

• endomysial fibrosis in the diaphragm is more severe than in single Dmd^mdx hemizygous males

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duchenne muscular dystrophy		DOID:11723	OMIM:310200	J:140282

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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