Phenotypes Associated with This Genotype

Genotype
MGI:5792143

• Allelic Composition: Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal associative learning ( J:234763 )

• mice show impaired associative memory

abnormal spatial reference memory ( J:234763 )

• mice show impaired preference for the target quadrant in the probe test of the Morris Water Maze indicating impaired spatial memory function

hyperactivity ( J:234763 )

• mild hyperactivity

cellular

abnormal cell physiology ( J:234763 )

• mice show an increase in the immunoreactivity to Tom20, a marker for mitochondrial localization, in the soma, indicating accumulation of mitochondria at the somata of nerve cells and impaired mitochondrial trafficking

homeostasis/metabolism

amyloid beta deposits ( J:234763 )

• amyloid beta plaque

nervous system

amyloid beta deposits ( J:234763 )

• amyloid beta plaque

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:234763