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Phenotypes Associated with This Genotype
Genotype
MGI:5791061
Allelic
Composition
Col1a1M1Jrt/Col1a1+
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1M1Jrt mutation (1 available); any Col1a1 mutation (161 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice exhibit substantial limping
• mice show decreased rearing attempts
• mice travel less distance in the open field glass chamber compared to wild-type mice
• overall counts of rotations in a home cage running wheel for one hour are reduced
• mice show decreased paw withdrawal thresholds to mechanical stimulation indicating increased sensitivity to mechanical stimuli
• mice show decreased withdrawal latency to heat stimuli indicating increased heat sensitivity
• mice show increased behavioral responses to acetone indicating increased sensitivity to cold stimuli

growth/size/body

homeostasis/metabolism
• improper healing of the femur at the hip joint
• hyperplastic callus formation of olecranon process

immune system
• arthritic knees

limbs/digits/tail
• hindpaw bone deformities
• deformity and fracture of olecranon processes
• hyperplastic callus formation of olecranon process

skeleton
• improper healing of the femur at the hip joint
• hyperplastic callus formation of olecranon process
• arthritic knees
• deformity and fracture of olecranon processes
• hyperplastic callus formation of olecranon process
• reduction in cervical intervertebral disc space
• scoliosis-like spine deformity
• decrease in bone volume/tissue volume
• decrease in cortical thickness
• atlanto-occipital joint dislocation
• deformity and fracture of olecranon processes
• tarsal-metatarsal fracture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
osteogenesis imperfecta type 4 DOID:0110340 OMIM:166220
J:228439


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory