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Phenotypes Associated with This Genotype
Genotype
MGI:5784770
Allelic
Composition		 Hrastm1Jaf/Hrastm1Jaf
Nf2tm2Gth/Nf2tm2Gth
Tg(TPO-cre)1Shk/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm1Jaf mutation (0 available); any Hras mutation (29 available)
Nf2tm2Gth mutation (3 available); any Nf2 mutation (67 available)
Tg(TPO-cre)1Shk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
increased thyroid tumor incidence ( J:231492 )
• mice develop large thyroid cancers with high penetrance, with most being poorly differentiated thyroid cancer
• treatment with AZD6244 results in a reduction of tumor size

neoplasm
increased thyroid tumor incidence ( J:231492 )
• mice develop large thyroid cancers with high penetrance, with most being poorly differentiated thyroid cancer
• treatment with AZD6244 results in a reduction of tumor size

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
thyroid cancer DOID:1781 J:231492

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory