Phenotypes Associated with This Genotype

Genotype
MGI:5775979

hm1

• Allelic Composition: Chd4^{Gt(RRO120)Byg}/Chd4^{Gt(RRO120)Byg}
• Genetic Background: B6.129P2-Chd4^{Gt(RRO120)Byg}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:224146 )

• although present at E3.5, no mice are present at E4.5

embryo

absent blastocoele ( J:224146 )

abnormal extraembryonic tissue physiology ( J:224146 )

• E3.5 blastocysts fail to attach and outgrow in culture after removal of zona pellucida indicating failure of trophectoderm function

cellular

increased apoptosis ( J:224146 )

• in blastocysts