Phenotypes Associated with This Genotype

Genotype
MGI:5771696

• Allelic Composition: Aspa^nur7/Aspa^nur7; Nat8l^tm1.2Meck/Nat8l^tm1.2Meck
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:226682 )

• reduced lifespan

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:226682 )

N • mice exhibit normal sphingolipid composition

abnormal enzyme/coenzyme level ( J:226682 )

• N-acetylaspartate levels in the brain are absent

behavior/neurological

behavior/neurological phenotype ( J:226682 )

N • mice exhibit normal rearing, normal total distance traveled, and normal latency to fall off the rotarod

growth/size/body

growth/size/body region phenotype ( J:226682 )

N • normal body weight

nervous system

nervous system phenotype ( J:226682 )

N • mice do not develop spongy degeneration or vacuolation in the brain and myelin structure appears normal with no demyelination

N • mice exhibit normal thickness of myelin sheaths relative to axon caliber, and do not exhibit axonal degeneration or astrogliosis

abnormal astrocyte morphology ( J:226682 )

• enlargement of pale astrocytic somata extending unusually broad processes that tend to group neighboring axons into microfascicles

cellular

abnormal astrocyte morphology ( J:226682 )

• enlargement of pale astrocytic somata extending unusually broad processes that tend to group neighboring axons into microfascicles