Phenotypes Associated with This Genotype

Genotype
MGI:5755137

• Allelic Composition: Dp(7Herc2-Mkrn3)1Taku/0
• Genetic Background: B6J.129S7-Dp(7Herc2-Mkrn3)1Taku

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal eye blink conditioning behavior ( J:225285 )

♂ • mice with a paternally inherited duplication (patDp/+) exhibit impaired delay eye blink conditioning, showing fewer conditioned responses than wild-type mice

♂ • impairments in learning in patDp/+ mice are specific to de novo acquisition and are not accompanied by deficiencies in blink representation, extinction, or re-acquisition

abnormal locomotor behavior ( J:225285 )

• patDp/+ mice exhibit a greater stance width in the forelimbs during locomotion, longer stride length, reduced stride frequency, and enhanced propulsion duration, indicating a mild motor impairment

long stride length ( J:225285 )

• patDp/+ mice show a longer stride length

nervous system

abnormal Purkinje cell innervation ( J:225285 )

• young patDP/+ mice exhibit a higher number of Purkinje cells that are innervated by multiple climbing fibers than in wild-type mice, suggesting impaired synaptic pruning, while adults mice show climbing fiber elimination, a mild impairment of the pruning process persists

• however, patDP/+ mice do not exhibit cerebellar or Purkinje cell dendrite abnormalities

abnormal long-term depression ( J:225285 )

• long-term depression at cerebellar parallel fiber-Purkinje cell synapses is impaired, however LTP is unaffected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:225285