Phenotypes Associated with This Genotype

Genotype
MGI:5751602

• Allelic Composition: Rgs18^tm1.1Ics/Rgs18^tm1.1Ics
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal bone marrow cell morphology/development ( J:225296 )

• defective megakaryopoiesis

abnormal megakaryocyte differentiation ( J:225296 )

• reduced frequency of megakaryocyte precursors with >2N DNA content

decreased megakaryocyte cell number ( J:225296 )

• in the bone marrow

thrombocytopenia ( J:225296 )

• mild in untreated mice

• after acute thrombocytopenia by GpIb antibody injection or intraperitoneal injection of busulfan

increased platelet aggregation ( J:225296 )

• spontaneously

• in a silk thread arterio-venous shunt thrombosis model with a more than 2 times increase in thrombi area

behavior/neurological

behavior/neurological phenotype ( J:225296 )

N • mice exhibit normal behavior in an open field test

increased startle reflex ( J:225296 )

decreased thermal nociceptive threshold ( J:225296 )

nervous system

nervous system phenotype ( J:225296 )

N • mice exhibit normal prepulse inhibition

homeostasis/metabolism

increased platelet aggregation ( J:225296 )

• spontaneously

• in a silk thread arterio-venous shunt thrombosis model with a more than 2 times increase in thrombi area

cellular

abnormal megakaryocyte differentiation ( J:225296 )

• reduced frequency of megakaryocyte precursors with >2N DNA content