Phenotypes Associated with This Genotype

Genotype
MGI:5707296

tg2

• Allelic Composition: Tg(APOE_i3*,APOC1)2Lmh/?
• Genetic Background: involves: C57BL/6J * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:228420 )

♀ • females develop atherosclerotic lesions after 20 weeks on Western diet

♀ • phenotype is less severe than in transgenic Tg(Alb-MYLIP*)1Pton mice

increased susceptibility to atherosclerosis ( J:228420 )

♀

homeostasis/metabolism

increased circulating cholesterol level ( J:228420 )

♀ • increased plasma cholesterol levels after 20 weeks on western diet

increased circulating LDL cholesterol level ( J:228420 )

♀ • LDL cholesterol levels are increased after 20 weeks on western diet as compared to wild-type

increased circulating VLDL cholesterol level ( J:228420 )

♀ • increased VLDL cholesterol levels after 20 weeks on western diet

♀ • VLDL fraction is higher than the level observed in transgenic Tg(Alb-MYLIP*)1Pton mice, although total cholesterol and LDL fractions are similar

increased circulating triglyceride level ( J:228420 )

♀ • increased plasma triglyceride levels after 20-30 weeks on western diet