Phenotypes Associated with This Genotype

Genotype
MGI:5698931

• Allelic Composition: Arhgap42^{Gt(CE0477)Wtsi}/Arhgap42^{Gt(CE0477)Wtsi}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

increased systemic arterial blood pressure ( J:221301 )

• by 20-30 mm Hg (or 15 mm Hg in heterozygotes)

• pressure normalized within 90 minutes of treatment with Rho kinase inhibitor "fasudil"

• Rho kinase inhibitor Y27632 also normalizes blood pressure

• adrenergic blocker prazosine lowers blood pressure but does not normalize blood pressure

increased mean systemic arterial blood pressure ( J:221301 )

increased systemic arterial diastolic blood pressure ( J:221301 )

increased systemic arterial systolic blood pressure ( J:221301 )

increased vasoconstriction ( J:221301 )

• vascular smooth muscle displays increased contractility

renal/urinary system

renal/urinary system phenotype ( J:221301 )

N • normal kidney structure and function

muscle

increased vasoconstriction ( J:221301 )

• vascular smooth muscle displays increased contractility