Phenotypes Associated with This Genotype

Genotype
MGI:5695366

• Allelic Composition: Rasgrp1^tm1.1Wz/Rasgrp1^tm1.1Wz
• Genetic Background: B6.Cg-Rasgrp1^tm1.1Wz

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:225109 )

N • total thymic cellularity is unaffected

abnormal immune system cell morphology ( J:225109 )

abnormal T cell differentiation ( J:225109 )

abnormal CD4-positive T cell differentiation ( J:225109 )

• CD4 thymocytes reduced by 4.6% rather than 8.7%

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225109 )

• moderate reduction of CD8+ thymocytes, by 1.3% as compared to 2.4%

increased CD4-positive, alpha-beta memory T cell number ( J:225109 )

• increased number of CD4+ cells with an activated memory phenotype

decreased single-positive T cell number ( J:225109 )

• peripheral CD4+ and CD8+ numbers are reduced modestly in younger mice

increased single-positive T cell number ( J:225109 )

• significantly increased numbers of CD4+ cells by 6 months of age

• CD4+ numbers are preferentially expanded relative to CD8+ cells

abnormal immune system organ morphology ( J:225109 )

enlarged spleen ( J:225109 )

• beginning at about 3-4 months of age

increased spleen weight ( J:225109 )

• greatly increased spleen weights at 6 months of age

abnormal immune system physiology ( J:225109 )

decreased T cell proliferation ( J:225109 )

• slight impairment after stimulation

• impairment greater for CD4+ than for CD8+

abnormal immunoglobulin level ( J:225109 )

increased IgE level ( J:225109 )

increased IgG1 level ( J:225109 )

increased autoantibody level ( J:225109 )

hematopoietic system

decreased T cell proliferation ( J:225109 )

• slight impairment after stimulation

• impairment greater for CD4+ than for CD8+

enlarged spleen ( J:225109 )

• beginning at about 3-4 months of age

increased spleen weight ( J:225109 )

• greatly increased spleen weights at 6 months of age

abnormal T cell differentiation ( J:225109 )

abnormal CD4-positive T cell differentiation ( J:225109 )

• CD4 thymocytes reduced by 4.6% rather than 8.7%

abnormal CD8-positive, alpha-beta T cell differentiation ( J:225109 )

• moderate reduction of CD8+ thymocytes, by 1.3% as compared to 2.4%

increased CD4-positive, alpha-beta memory T cell number ( J:225109 )

• increased number of CD4+ cells with an activated memory phenotype

decreased single-positive T cell number ( J:225109 )

• peripheral CD4+ and CD8+ numbers are reduced modestly in younger mice

increased single-positive T cell number ( J:225109 )

• significantly increased numbers of CD4+ cells by 6 months of age

• CD4+ numbers are preferentially expanded relative to CD8+ cells

abnormal immunoglobulin level ( J:225109 )

increased IgE level ( J:225109 )

increased IgG1 level ( J:225109 )

cellular

decreased T cell proliferation ( J:225109 )

• slight impairment after stimulation

• impairment greater for CD4+ than for CD8+

growth/size/body

enlarged spleen ( J:225109 )

• beginning at about 3-4 months of age

increased spleen weight ( J:225109 )

• greatly increased spleen weights at 6 months of age