Phenotypes Associated with This Genotype

Genotype
MGI:5661383

• Allelic Composition: Fgf10^tm1Ska/Fgf10^tm1Ska; Fgf8^tm1Moon/Fgf8^tm1Moon; Mesp1^tm2(cre)Ysa/Mesp1⁺
• Genetic Background: involves: C57BL/6NCrlj * CBA/JNCrlj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aortic arch morphology ( J:170879 )

• narrow

aberrant origin of the right subclavian artery ( J:170879 )

abnormal common carotid artery morphology ( J:170879 )

• absence of the left common carotid artery in some mice

abnormal cardiovascular development ( J:170879 )

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac epithelial to mesenchymal transition ( J:170879 )

• impaired at E10.5

abnormal cardiac outflow tract development ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

• smaller and misshapen at E10.5

double outlet right ventricle ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

ventricular septal defect ( J:170879 )

• more frequent than in mutant mice wild-type for Fgf10

decreased heart right ventricle size ( J:170879 )

• hypomorphic at E9.5

• more severe than in mutant mice wild-type for Fgf10

craniofacial

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )

cellular

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

embryo

abnormal pharyngeal arch artery morphology ( J:170879 )

• various defects are detected at E10.5, including missing third, fourth and sixth PAAs and retention of the second PAA

• incidence of defects is increased compared to mutant mice wild-type for Fgf10

abnormal fourth pharyngeal arch artery morphology ( J:170879 )

abnormal sixth pharyngeal arch artery morphology ( J:170879 )

abnormal third pharyngeal arch artery morphology ( J:170879 )

abnormal cardiac neural crest cell migration ( J:170879 )

• compromised invasion of the outflow tract at E10.5

second pharyngeal arch hypoplasia ( J:170879 )

third pharyngeal arch hypoplasia ( J:170879 )