Phenotypes Associated with This Genotype

Genotype
MGI:5649153

• Allelic Composition: Krt90^whnl/Krt90^whnl
• Genetic Background: involves: MRL/MpJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Rear paw of Krt90^whnl/Krt90^whnl mouse showing very long nails

integument

abnormal nail morphology ( J:223505 )

long toenails ( J:223505 )

• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated

mortality/aging

prenatal lethality, incomplete penetrance ( J:223505 )

• fewer than 10 percent of offspring from heterozgyous intercrosses were homozygotes

vision/eye

vision/eye phenotype ( J:223505 )

N • ophthalmoscopic examination of the eyes of 2 homozygotes at 4 months of age found no abnormality

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:223505 )

N • ABR threshold assessment on 2 homozygotes at 4 months of age found no abnormality

limbs/digits/tail

long toenails ( J:223505 )

• all homozygotes develop very long nails on all digits by 2 months of age and although the nail bed is normal the nail is thickened and elongated

increased caudal vertebrae number ( J:223505 )

• X-rays of 5 homozogytes showed additional caudal vertebrae in some but not all mutants

skeleton

increased caudal vertebrae number ( J:223505 )

• X-rays of 5 homozogytes showed additional caudal vertebrae in some but not all mutants