Phenotypes Associated with This Genotype

Genotype
MGI:5645058

• Allelic Composition: Cebpa^tm1Gonz/Cebpa^tm1Gonz; Tg(KRT14-cre/ERT)20Efu/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

increased keratinocyte proliferation ( J:158721 )

• 4OHT-treated mutant mice show a significant increase in the number of BrdU positive basal keratinocytes relative to controls

integument

integument phenotype ( J:158721 )

N • 4OHT-treated mutant mice show no major changes in the morphology of interfollicular epidemis, outer root sheath of the hair follicle, and sebaceous glands relative to controls

N • normal IHC staining for K5, K10, loricrin and involucrin is observed in epidermis

increased keratinocyte proliferation ( J:158721 )

• 4OHT-treated mutant mice show a significant increase in the number of BrdU positive basal keratinocytes relative to controls

epidermal hyperplasia ( J:158721 )

• 4OHT-treated mutant mice show a significant increase in the number of nucleated cell layers relative to controls

thick epidermis ( J:158721 )

• 4OHT-treated mutant mice show a moderate increase in epidermal thickness relative to controls