Phenotypes Associated with This Genotype

Genotype
MGI:5635161

• Allelic Composition: Tg(HTT*)LXwy/0
• Genetic Background: involves: FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:219890 )

• premature lethality around 5 months of age

behavior/neurological

dystonia ( J:219890 )

• mice show sustained retroflex of head and neck indicating cervical dystonia at 4-5 months of age

abnormal head movements ( J:219890 )

• mice show chorea/dystonia-like head movements starting at 4-5 months of age

growth/size/body

weight loss ( J:219890 )

• body weight loss at 5 months of age

muscle

dystonia ( J:219890 )

• mice show sustained retroflex of head and neck indicating cervical dystonia at 4-5 months of age

nervous system

abnormal forebrain morphology ( J:219890 )

• mice show forebrain weight loss with modest cerebellar weight loss

neuronal intranuclear inclusions ( J:219890 )

• nuclear inclusions containing aggregated mutant HTT are seen in both the cortex and striatum

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:219890