Phenotypes Associated with This Genotype

Genotype
MGI:5632129

• Allelic Composition: Trp53^tm1Brn/Trp53^tm1Brn; Tsc1^tm1Djk/Tsc1^tm1Djk
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:212578 )

• mice injected with adenovirus expressing Cre (AdCre) into the bladder at 2-3 months of age start to die at 6 months of age and have a median survival of 10.2 months

• mice injected with AdCre intraperitoneally exhibit a median survival of 8.5 months and 89% of mice die during one year of follow-up after AdCre injection

neoplasm

increased mesothelioma incidence ( J:212578 )

• 73% of mice injected with AdCre into the bladder exhibit mesothelioma

• 85% of mice injected with AdCre intraperitoneally develop mesothelioma

• malignant tumor, similar to epithelioid mesothelioma, is seen on all peritoneal surfaces, including the bladder, kidney, spleen, liver and intestines, without evidence of a primary site, in mice injected with AdCre

• mice that develop mesothelioma following AdCre injection and are treated with rapamycin for 5 weeks show inhibition of tumor growth

homeostasis/metabolism

hemorrhagic ascites ( J:212578 )

• mice injected with AdCre into the bladder often exhibit hemorrhagic ascites

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
malignant mesothelioma		DOID:1790	OMIM:156240	J:212578