Phenotypes Associated with This Genotype

Genotype
MGI:5578629

• Allelic Composition: Tg(CMV-IgkvaD11)BCat/Tg(CMV-IgkvaD11)BCat
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal object recognition memory ( J:212312 )

• 6 month old mice do not preferentially explore the new object during an object recognition test, spending an equal time exploring the new and the old object

cardiovascular system

impaired blood-brain barrier function ( J:212312 )

• the blood brain barrier shows increased permeability

homeostasis/metabolism

amyloid beta deposits ( J:212312 )

• intraneuronal amyloid beta is seen in the stratum radiatum and molecularis of the hippocampus, starting from 6 months of age

nervous system

impaired blood-brain barrier function ( J:212312 )

• the blood brain barrier shows increased permeability

amyloid beta deposits ( J:212312 )

• intraneuronal amyloid beta is seen in the stratum radiatum and molecularis of the hippocampus, starting from 6 months of age

small superior cervical ganglion ( J:212312 )

• size of the superior cervical ganglion is decreased due to extensive shrinkage of cell body

abnormal brain morphology ( J:212312 )

• free nerve growth factor (NGF) in the brain is reduced by 50% compared to wild-type mice

• mice show hybrid anti-NGF antibodies (human light chain and endogenous mouse heavy chain) that are first detected between 1.5 and 2 months of age, both in serum and in the brain

neurofibrillary tangles ( J:212312 )

• neurofibrillary alterations

tau protein deposits ( J:212312 )

• age-dependent increase of immunoreactivity against phosphorylated tau in the cortex and in the pyramidal layer of the hippocampus

• phosphorylated-tau immunoreactivity is mainly located in the neuronal cell bodies or in apical dendrites

abnormal innervation ( J:212312 )

• expression of tyrosine hydroxylase in perivascular sympathetic nerve fibers innervating the wall of the posterior cerebral arteries is decreased, indicating decreased innervation of the large cerebral arteries

abnormal cholinergic neuron morphology ( J:212312 )

• decrease in the number of ChAT-positive cholinergic neurons in the medial septum and diagonal band of Broca as early as 2 months of age

• morphology of cholinergic neurons in the medial septum is altered, with most of the neurons being shrunk

• peripherally administered nerve growth factor prevents cholinergic neuron degeneration

neurodegeneration ( J:212312 )

• cholinergic neuron degeneration

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:212312