Phenotypes Associated with This Genotype

Genotype
MGI:5578332

• Allelic Composition: Jun^tm4Wag/Jun^tm4Wag; Junb^tm3Wag/Junb^tm3Wag; Tg(Krt1-5-cre/ERT)1Ipc/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

skin inflammation ( J:116380 )

• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction

abnormal skin morphology ( J:116380 )

• mice treated with tamoxifen show an increase in subepidermal vascularization

hyperkeratosis ( J:116380 )

• thickening of keratinized upper layers in mice treated with tamoxifen

parakeratosis ( J:116380 )

• in mice treated with tamoxifen

thick epidermis ( J:116380 )

• mice treated with tamoxifen show thickened epidermis with prominent rete ridge

psoriasis ( J:116380 )

• mice treated with tamoxifen at 8 weeks of age develop psoriasis-like skin lesions on hairless skin 8-10 days after tamoxifen induction, showing scaly plaques affecting primarily ears, paws and tail, and less frequently the hairy back skin

immune system

increased inflammatory response ( J:116380 )

• periostitis in mice treated with tamoxifen

arthritis ( J:116380 )

• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions

skin inflammation ( J:116380 )

• intra-epidermal T cells, epidermal micro-abscesses and typical inflammatory-cell infiltrate consisting of neutrophils, and an increase in numbers of macrophages in the dermis are seen in mice 8-10 days after tamoxifen induction

skeleton

arthritis ( J:116380 )

• arthritic lesions similar to psoriatic arthritis are seen in 100% of mice treated with tamoxifen, showing inflammatory infiltrates in joint regions

abnormal bone structure ( J:116380 )

• massive bone destruction

abnormal periosteum morphology ( J:116380 )

• periostitis in mice treated with tamoxifen

cardiovascular system

abnormal blood vessel morphology ( J:116380 )

• mice treated with tamoxifen show an increase in subepidermal vascularization

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:116380