Phenotypes Associated with This Genotype

Genotype
MGI:5571874

cx2

• Allelic Composition: Rapgef3^tm1.2Chen/Rapgef3^tm1.2Chen; Rapgef4^tm1.2Chen/Rapgef4^tm1.2Chen
• Genetic Background: involves: 129 * Black Swiss * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:210426 )

N • mice exhibit normal baseline cardiac function and response to transverse aortic constriction

muscle

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished

cellular

abnormal sarcoplasmic reticulum morphology ( J:210426 )

• 8-CPT-induced increase in calcium spark frequency (a measure of sarcoplasmic leak) is abolished