Phenotypes Associated with This Genotype

Genotype
MGI:5571287

• Allelic Composition: Umod^Urehd1/Umod^Urehd1
• Genetic Background: involves: C3HeB/FeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:201084 )

• from 5 weeks of age onwards

homeostasis/metabolism

increased blood urea nitrogen level ( J:201084 )

• significant increase in male and female from 2 weeks of age onwards

• concentrations increase with age

• levels are higher than in heterozygous mutants and in mice homozygous for Umod^urehr4

renal/urinary system

renal tubular necrosis ( J:201084 )

♂ • at 20-22 months of age, more severe than heterozygous mutants

renal interstitial fibrosis ( J:201084 )

♂ • at 20-22 months of age, more severe than heterozygous mutants

decreased renal glomerular filtration rate ( J:201084 )

• elevated plasma cystatin C levels indicate decreased glomerular filtration rate at 4 months of age

cellular

renal tubular necrosis ( J:201084 )

♂ • at 20-22 months of age, more severe than heterozygous mutants

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
kidney disease		DOID:557		J:201084