Phenotypes Associated with This Genotype

Genotype
MGI:5563125

• Allelic Composition: Clcn7^tm1.1Mjec/Clcn7⁺
• Genetic Background: involves: 129 * 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

increased areal bone mineral density ( J:203761 )

• whole areal bone mineral density at 3 months of age is very high

• Background Sensitivity: 8% increase in whole body areal bone mineral density on the 129 background compared to 4% increase on a DBA/2J background and 3.8% on a BALB/cJ background

increased trabecular bone volume ( J:203761 )

increased bone trabecula number ( J:203761 )

decreased bone trabecular spacing ( J:203761 )

• trabecular separation is lower

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal dominant osteopetrosis 2		DOID:0110938	OMIM:166600	J:203761