About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5562921
Allelic
Composition		 Tg(SERPINA1*E342K)#Slcw/Tg(SERPINA1*E342K)#Slcw
Genetic
Background		 involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(SERPINA1*E342K)#Slcw mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
abnormal enzyme/coenzyme level ( J:208016 )
• mice show elevations in liver enzymes such as alanine transaminase and aspartate aminotransferase

liver/biliary system
liver fibrosis ( J:208016 )
• mice show liver fibrosis around 4 months of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
alpha 1-antitrypsin deficiency DOID:13372 OMIM:613490
 J:208016

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory