Phenotypes Associated with This Genotype

Genotype
MGI:5560479

• Allelic Composition: Tg(Cela1-luc,Cela1-TAg)#Nzh/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased ovary tumor incidence ( J:207960 )

♀ • about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age

increased pancreatic acinar cell carcinoma incidence ( J:207960 )

• mice develop acinar cell carcinoma with a latency of 10 to more than 20 weeks of age

• tumors are highly vascularized and necrosis is seen in some areas of tumors

• rapamycin treatment suppresses acinar cell carcinoma development

increased metastatic potential ( J:207960 )

• metastatic lesions to the liver and mesenteric fat tissue is seen and at late stages of tumor development, multiple metastatic lesions to fat tissues of the gastrointestinal tract and the reproductive organs are seen

endocrine/exocrine glands

increased ovary tumor incidence ( J:207960 )

♀ • about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age

increased pancreatic acinar cell carcinoma incidence ( J:207960 )

• mice develop acinar cell carcinoma with a latency of 10 to more than 20 weeks of age

• tumors are highly vascularized and necrosis is seen in some areas of tumors

• rapamycin treatment suppresses acinar cell carcinoma development

reproductive system

increased ovary tumor incidence ( J:207960 )

♀ • about 25% of females develop luciferase negative ovarian tumors by 21 to 23 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic carcinoma		DOID:4905	OMIM:260350	J:207960