Phenotypes Associated with This Genotype

Genotype
MGI:5559524

• Allelic Composition: Chd7^{tm2a(EUCOMM)Wtsi}/Chd7^{tm2a(EUCOMM)Wtsi}
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

embryonic growth arrest ( J:207089 )

• no apparent gross abnormality at E9.5 but fully penetrant growth arrest at E10.5

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:207089 )

• at E10.5

cellular

decreased fetal cardiomyocyte proliferation ( J:207089 )

• at E10.0

increased cardiomyocyte apoptosis ( J:207089 )

• at E10.0

abnormal epigenetic regulation of gene expression ( J:207089 )

• significantly reduced active epigenetic state of Nkx2-5 enhancers in E10.0 hearts

cardiovascular system

cardiovascular system phenotype ( J:207089 )

N • no myocardial defect at E9.5

thin myocardium ( J:207089 )

• at E10.5, mutant displays hypocellular myocardial wall

atrioventricular cushion hypoplasia ( J:207089 )

• fewer mesenchymal cells present in AV cushions at E9.5

• at E10.5, mutant displays hypocellular AV cushions

decreased fetal cardiomyocyte proliferation ( J:207089 )

• at E10.0

muscle

thin myocardium ( J:207089 )

• at E10.5, mutant displays hypocellular myocardial wall

decreased fetal cardiomyocyte proliferation ( J:207089 )

• at E10.0

increased cardiomyocyte apoptosis ( J:207089 )

• at E10.0