Phenotypes Associated with This Genotype

Genotype
MGI:5559468

• Allelic Composition: Tg(KRT14-HPV8)#Vuc/0
• Genetic Background: involves: C57BL/6 * DBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal epidermal layer morphology ( J:96784 )

• epidermis shows multiple cavities, filled with lamellated concentric keratin masses

• koilocytosis occurs in some areas

hyperkeratosis ( J:96784 )

parakeratosis ( J:96784 )

increased keratohyalin granule number ( J:96784 )

• intracytoplasmic keratohyaline granules are present in the upper layers and in the epithelium surrounding the hair shafts

acanthosis ( J:96784 )

dyskeratosis ( J:96784 )

increased skin tumor incidence ( J:96784 )

• 91% of mice develop skin tumors

• tumor growth generally starts in the dorsocaudal region of the trunk, with alopecia and hyperkeratosis, continues to become more hyperkeratotic and spread diffusely or multifocally to the cranial and ventral regions of the body

• males develop tumors earlier than females

increased skin papilloma incidence ( J:96784 )

• papillomas with hyperkeratosis, dyskeratosis, and parakeratosis

• different degrees of dysplasia is seen in the papillomas; mild dysplasia consists of atypia in the basal layer, mild hyperchromatosis and anisonucleosis, moderate dysplasia with atypical cells in the middle layers of the epithelium, and high grade dysplasia with loss of stratification of the epithelium and atypical cells with hyperchromatic and pleomorphic nuclei

increased skin squamous cell carcinoma incidence ( J:96784 )

• 6% of mice develop squamous cell carcinomas

neoplasm

increased skin tumor incidence ( J:96784 )

• 91% of mice develop skin tumors

• tumor growth generally starts in the dorsocaudal region of the trunk, with alopecia and hyperkeratosis, continues to become more hyperkeratotic and spread diffusely or multifocally to the cranial and ventral regions of the body

• males develop tumors earlier than females

increased skin papilloma incidence ( J:96784 )

• papillomas with hyperkeratosis, dyskeratosis, and parakeratosis

• different degrees of dysplasia is seen in the papillomas; mild dysplasia consists of atypia in the basal layer, mild hyperchromatosis and anisonucleosis, moderate dysplasia with atypical cells in the middle layers of the epithelium, and high grade dysplasia with loss of stratification of the epithelium and atypical cells with hyperchromatic and pleomorphic nuclei

increased skin squamous cell carcinoma incidence ( J:96784 )

• 6% of mice develop squamous cell carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin cancer		DOID:4159		J:96784