Phenotypes Associated with This Genotype

Genotype
MGI:5559465

• Allelic Composition: Tg(KRT14-HPV8)85Vuc/0
• Genetic Background: FVB.Cg-Tg(KRT14-HPV8)85Vuc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

alopecia ( J:96784 )

hyperkeratosis ( J:96784 )

• develop severe hyperkeratosis leading to cutaneous horns

increased skin papilloma incidence ( J:96784 )

• Background Sensitivity: mice show a higher penetrance of papilloma development on the FVB/N background than on the C57BL/6 background; papillomas present with mild or moderate dysplasia

• develop lesions on the laterodorsal trunk at 28 weeks of age

• males develop tumors earlier than females

increased skin squamous cell carcinoma incidence ( J:96784 )

• 2 of 85 mice that develop papilloma show invasive squamous cell carcinoma

neoplasm

increased skin papilloma incidence ( J:96784 )

• Background Sensitivity: mice show a higher penetrance of papilloma development on the FVB/N background than on the C57BL/6 background; papillomas present with mild or moderate dysplasia

• develop lesions on the laterodorsal trunk at 28 weeks of age

• males develop tumors earlier than females

increased skin squamous cell carcinoma incidence ( J:96784 )

• 2 of 85 mice that develop papilloma show invasive squamous cell carcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
skin cancer		DOID:4159		J:96784