Phenotypes Associated with This Genotype

Genotype
MGI:5559171

• Allelic Composition: Ampd2^tm1Tm/Ampd2^tm1Tm; Ampd3^{tm2a(KOMP)Wtsi}/Ampd3^{tm2a(KOMP)Wtsi}
• Genetic Background: involves: 129S2/SvPas * C57BL/6N
• Cell Lines: EPD0043_3_B02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:200072 )

• lifespan is limited to 2 to 3 weeks

nervous system

neurodegeneration ( J:200072 )

• after P14, mostly affecting the CA3 pyramidal neurons in the hippocampus with some pyknotic cells in the cortex and cerebellum

behavior/neurological

abnormal gait ( J:200072 )

growth/size/body

decreased body weight ( J:200072 )

• slight

homeostasis/metabolism

abnormal nucleotide metabolism ( J:200072 )

• increased ATP nucleotide levels in the brain at 2 weeks

• decreased GTP nucleotide levels in the brain at 2 weeks