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Phenotypes Associated with This Genotype
Genotype
MGI:5532656
cn69
Allelic
Composition		 Axin2tm1.1(cre/ERT2/tdTomato)Eem/Axin2+
Ctnnb1tm2Kem/Ctnnb1tm2Kem
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin2tm1.1(cre/ERT2/tdTomato)Eem mutation (0 available); any Axin2 mutation (45 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased cell proliferation ( J:204142 )
• epidermis where Ctnnb1 is deleted (following tamoxifen induction) exhibits significantly reduced cell proliferation (>40%) relative to control epidermis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory