Phenotypes Associated with This Genotype

Genotype
MGI:5523996

• Allelic Composition: Scn1a^tm1Kea/Scn1a⁺
• Genetic Background: (C57BL/6J x 129S6/SvEvTac-Scn1a^tm1Kea)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit premature death with 50% of mice dying by 1 month of age unlike mice on a coisogenic 129S6/SvEvTac background

behavior/neurological

seizures ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

nervous system

seizures ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dravet syndrome		DOID:0080422	OMIM:607208	J:203040