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Phenotypes Associated with This Genotype
Genotype
MGI:5523888
Allelic
Composition		 Scn1atm2.1Kzy/Scn1a+
Tg(Pvalb-cre)1Tama/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn1atm2.1Kzy mutation (1 available); any Scn1a mutation (113 available)
Tg(Pvalb-cre)1Tama mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:202863 )
• some mice develop recurrent seizures after P16

mortality/aging
postnatal lethality ( J:202863 )
• some mice develop recurrent seizures after P16 and experience sporadic sudden death

nervous system
convulsive seizures ( J:202863 )
• some mice develop recurrent seizures after P16

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Dravet syndrome DOID:0080422 OMIM:607208
 J:202863

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory