Phenotypes Associated with This Genotype

Genotype
MGI:5515882

cx2

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(Lor-CHUK)8Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:197037 )

• mice do not live longer than 7 or 8 months

neoplasm

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

respiratory system

enlarged lung ( J:197037 )

• associated with tumor development

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

immune system

absent lymph nodes ( J:197037 )

integument

integument phenotype ( J:197037 )

N • mice do not develop skin phenotype observed in Chuk^tm2Yhu homozygotes

growth/size/body

enlarged lung ( J:197037 )

• associated with tumor development