Phenotypes Associated with This Genotype

Genotype
MGI:5495975

hm1

• Allelic Composition: Palb2^tm1.2Dli/Palb2^tm1.2Dli
• Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size and exencephaly in Palb2^tm1.2Dli/Palb2^tm1.2Dli E10.5 embryos

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:197442 )

• mice are only recovered up to E12.5

embryonic lethality, incomplete penetrance ( J:197442 )

• fewer than expected mice are recovered up to E12.5

embryo

abnormal placental labyrinth vasculature morphology ( J:197442 )

abnormal vitelline vasculature morphology ( J:197442 )

abnormal embryo development ( J:197442 )

• multiple malformations at E9.5

decreased embryo size ( J:197442 )

• at E10.5

nervous system

exencephaly ( J:197442 )

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:197442 )

abnormal vitelline vasculature morphology ( J:197442 )

growth/size/body

decreased embryo size ( J:197442 )

• at E10.5