Phenotypes for Gja8 MGI:5489760 MGI Mouse

About Help FAQ

Phenotypes Associated with This Genotype

Allelic Composition	Gja8^R205G/Gja8^R205G
Genetic Background	B6.Cg-Gja8^R205G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja8^R205G mutation (1 available); any Gja8 mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Dense nuclear cataracts in Gja8^R205G/Gja8^R205G and Gja8^R205G/Gja8^R205G Gja3^tm1Scr/Gja3^tm1Scr mice but degenerating peripheral lens fibers only in Gja8^R205G/Gja8^R205G mice

vision/eye

lens vacuoles ( J:195727 )

• aberrant vacuole-like structures in the lens periphery

nuclear cataract ( J:195727 )

• dense

small lens ( J:195727 )

microphthalmia ( J:195727 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 1 multiple types		DOID:0110231	OMIM:116200	J:195727

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/30/2025 MGI 6.24