Phenotypes for Batf3 Id2 MGI:5486201 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Batf3^tm1Kmm/Batf3^tm1Kmm Id2^tm1Gtbz/Id2^tm1Gtbz
Genetic Background	B6.Cg-Batf3^tm1Kmm Id2^tm1Gtbz

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Batf3^tm1Kmm mutation (4 available); any Batf3 mutation (20 available)
Id2^tm1Gtbz mutation (0 available); any Id2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:194760 )

• in reconstitution assays, CD8alpha+ dendritic cells generate from transplanted bone marrow cells fail to survive long-term

• CD8alpha+ dendritic cells exhibit impaired cell-associated cross-presentation compared with control cells

• however, cells exhibit normal soluble cross-presentation and cell-associated antigen cross-presentation during GVHD or HSV-1 viral antigens

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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